Exploiting gasdermin-mediated pyroptosis for enhanced antimicrobial activity of phage endolysin against Pseudomonas aeruginosa
ABSTRACT Pyroptosis is an inflammatory immune response of eukaryotic cells to bacterial lipopolysaccharide (LPS) and other pathological stimuli, leading to the activation of the gasdermin D (GSDMD) and secretion Herbal Medicine of pore-forming domain GSDMDNterm, facilitating the release of cytokines.Additionally, GSDMDNterm exhibits antibacterial p